吴高松

吴高松，副研究员

基本信息

办公电话：021-51322770

电子邮箱：gaosong@shutcm.edu.cn

通讯地址：上海市浦东新区蔡伦路1200号

招生专业

研究方向：中药药效物质基础关键技术及机制研究

院系名称：伟德国际官方入口

学位类型：学术学位

专业名称：中药学/100800

教育经历

2011.09-2015.06, 黑龙江中医药大学，中药学，学士

2015.08-2018.06, 黑龙江中医药大学，中药化学，硕士

2018.09-2021.06, 上海中医药大学, 中药学, 博士

任职经历

2021.07-2023.11, 上海中医药大学, 交叉科学研究院, 博士后

2023.12-2023.12, 上海中医药大学, 伟德国际官方入口, 助理研究员

2024.01-至今, 上海中医药大学, 伟德国际官方入口, 副研究员

获项及荣誉

betvlctor伟德国际副研究员，目前主持国家自然科学青年基金1项，参与国家重点研发计划课题1项（任务负责人），曾获得上海市超级博士后资助。目前的研究方向为中药药效物质基础关键技术和机制研究，致力于应用代谢组学、肠道微生物组学等多组学技术研究中药的药效物质和药效机理。近五年以第一或通讯作者在Anal Chem、Phytomedicine、Phytother Res、J Ethnopharmacol等期刊发表SCI论文15篇。

承担科研项目情况

1. 国家自然科学基金青年基金，麝香保心丸通过富集乳酸杆菌激活AMPK通路调控棕色脂肪治疗冠心病的机制研究(82304753)，主持

2. 上海市人力资源和社会保障局超级博士后项目，基于功能代谢组学的麝香保心丸治疗冠心病的机制研究(2021314)，主持

3. 国家科学技术部，中成药系统生物学数据整合与人工智能应用平台构建(2022YFC3502005)，任务负责人

主要代表性成果

1. Gaosong Wu1, Jingyu Liao1, Xiaoyan Zhu1, Yuhao Zhang1, Yuan Lin, Yuanyuan Zeng, Jing Zhao, Jingfang Zhang, Tingting Yao, Xiaoxu Shen*, Houkai Li*, Liang Hu*, Weidong Zhang*. Shexiang Baoxin Pill enriches Lactobacillus to regulate purine metabolism in patients with stable coronary artery disease. Phytomedicine. 2024; 130: 155727. (IF = 6.7)

2. Yuhao Zhang1, Jingyu Liao1, Wanqi Le, Gaosong Wu*, Weidong Zhang*. Improving the data quality of untargeted metabolomics through a targeted data-dependent acquisition based on an inclusion list of differential and preidentified ions. Anal Chem. 2023; 95(34):12964-12973. (IF = 6.7)

3. Jingyu Liao, Yuhao Zhang, Chi Ma, Gaosong Wu*, Weidong Zhang*. Microbiome-metabolome reveals that the Suxiao Jiuxin pill attenuates acute myocardial infarction associated with fatty acid metabolism. J Ethnopharmacol, 2023, 312:116529. (IF = 4.8)

4. Gaosong Wu1, Wendan Zhang1, Ningning Zheng1, Xianpeng Zu, Saisai Tian, Jing Zhong, Yuhao Zhang, Jingyu Liao, Lili Sheng, Guanbo Ge, Houkai Li*, Weidong Zhang*. Integrated microbiome and metabolome analysis reveals the potential therapeutic mechanism of Qing-Fei-Pai-Du decoction in mice with coronavirus-induced pneumonia. Front Cell Infect Microbiol. 2022; 12: 950983. (IF = 5.7)

5. Gaosong Wu1, Jing Zhong1, Linlin Chen, Yu Gu, Ying Hong, Junli Ma, Ningning Zheng, Ai-Jun Liu, Lili Sheng, Weidong Zhang*, Houkai Li*. Effects of the Suxiao Jiuxin pill on acute myocardial infarction assessed by comprehensive metabolomics. Phytomedicine. 2020; 77: 153291. (IF = 5.34)

6. Gaosong Wu1, Linlin Chen1, Yu Gu, Ying Hong, Junli Ma, Ningning Zheng, Jing Zhong, Ai-Jun Liu, Lili Sheng, Weidong Zhang*, Houkai Li*. Exploring the mechanism underlying the cardioprotective effect of shexiang baoxin pill on acute myocardial infarction rats by comprehensive metabolomics. J Ethnopharmacol. 2020; 259: 113001. (IF = 4.36)

7. Gaosong Wu1, Jing Zhao1, Jing Zhao1, Nixue Song1, Ningning Zheng, Yuanyuan Zeng, Tingting Yao, Jingfang Zhang, Jieqiong Weng, Mengfei Yuan, Hu Zhou, Xiaoxu Shen*, Houkai Li*, Weidong Zhang*. Exploring biological basis of syndrome differentiation in coronary heart disease patients with two distinct syndromes by integrated multi-omics and network pharmacology strategy. Chin Med. 2021; 16 (1): 109. (IF = 4.55)

8. Jingyu Liao1, Yuhao Zhang1, Wendan Zhang1, Yuanyuan Zeng, Jing Zhao, Jingfang Zhang, Tingting Yao, Houkai Li, Xiaoxu Shen, Gaosong Wu*, Weidong Zhang*. Different software processing affects the peak picking and metabolic pathway recognition of metabolomics data. J Chromatogr A. 2023; 1687: 463700. (IF = 4.1)