张永太,教授
基本信息
办公电话:021-51322210
电子邮箱:analysisdrug@126.com
通讯地址:上海市浦东新区蔡伦路1200号
招生专业
研究方向:中药新型给药系统与穴位给药理论
院系名称:伟德国际官方入口
学位类型:学术学位
专业名称:中药学/100800
1998.09-2002.07, 山东中医药大学, 中药学, 学士
2002.09-2005.07, 南京中医药大学, 中药学, 硕士
2008.09-2012.07, 上海中医药大学, 中药学, 博士
任职经历
2005.08-2007.12, 上海中医药大学, 伟德国际官方入口, 助教
2008.01-2012.12, 上海中医药大学, 伟德国际官方入口, 讲师
2013.09-2014.07, 复旦大学, 药学院, 访问学者
2015.10-2016.10, 美国密歇根大学安娜堡分校, 药学院, 访问学者
2013.01-2019.12, 上海中医药大学, 伟德国际官方入口, 副教授
2020.01-至今, 上海中医药大学, 伟德国际官方入口, 教授
获项及荣誉
国家中医药管理局“岐黄工程”中药特色技术传承人才培训项目、上海市“东方学者”特聘教授、上海市“杏林专门人才”,获上海人才发展资金资助。
兼任上海市皮肤药理学会青年主任委员、世中联经皮给药委员会、儿童产业委员会常务理事等。
主要从事中药新型经皮给药系统与化妆品的研究。成功将微针、新型脂质纳米载体用于中药经皮与穴位给药系统的构建,并阐释穴位给药通过“神经-免疫-炎性因子”效应轴发挥经穴效应的机理;挖掘具有“药辅合一”特色的中药药/辅材料,开发了数十种中药新型经皮给药系统。在ACS Nano、J Control Release、Chem Eng J、Biomaterials、Acta Pharm Sin B等SCI源期刊上发表论文80余篇。曾获上海市科技进步奖、中华医学科技奖等奖励。
承担本科《中药药剂学》、《中药制药辅料学》、《医院药学实习》、《综合性实验》、《中药药剂学实验》及研究生《中药药剂学专论》的教学工作。担任科学出版社高等医药院校系列教材《中药制药辅料学》的共同主编,副主编中国中医药出版社十四五规划教材《物理药剂学》、《药用高分子材料学》、《药用辅料学》。以第一作者获上海市优秀教学论文奖。
承担科研项目情况
国家自然科学基金面上项目, 基于“药物转运—靶蛋白/代谢通路—外泌体信号”效应轴探索pH触发式释药水凝胶微针脐部给药的效应机制(82074031), 主持
国家自然科学基金面上项目, 基于microRNA/甲基化DNA谱与结肠动力学分析HA-GLY/LS载丁桂散脐部给药效应机制(81673612), 主持
国家自然科学基金青年项目, 丁桂散脐部给药散寒止痛作用机制评价研究(81303234), 主持
上海市东方学者资助项目(TP2020054), 主持
上海市人才发展资金(2018099), 主持
主要代表性成果
Tong Wu; Xiaolin Hou; Jiaqi Li; Hang Ruan; Lixia Pei; Teng Guo; Zhi Wang; Tianyuan Ci; Shuyao Ruan; Yuanzhi He; Zehui He; Nianping Feng*; Yongtai Zhang*; Microneedle-Mediated Biomimetic Cyclodextrin Metal Organic Frameworks for Active Targeting and Treatment of Hypertrophic Scars, ACS Nano, 2021, 15(12): 20087-20104
Qian Jing; Hang Ruan; Jiaqi Li; Zhi Wang; Lixia Pei; Hongmei Hu; Zehui He; Tong Wu; Shuyao Ruan; Teng Guo; Youjie Wang; Nianping Feng; Yongtai Zhang*; Keratinocyte membrane-mediated nanodelivery system with dissolving microneedles for targeted therapy of skin diseases, Biomaterials, 2021, 278: 121142
Hongmei Hu; Hang Ruan; Shuyao Ruan; Lixia Pei; Qian Jing; Tong Wu; Xiaolin Hou; Hao Xu; Youjie Wang; Nianping Feng; Yongtai Zhang*; Acid-responsive PEGylated branching PLGA nanoparticles integrated into dissolving microneedles enhance local treatment of arthritis, Chem Eng J, 2022, 431(2): 134196
Shuyao Ruan; Jiaqi Li; Hang Ruan; Qing Xia; Xiaolin Hou; Zhi Wang; Teng Guo; Chunyun Zhu; Nianping Feng*; Yongtai Zhang*; Microneedle-mediated nose-to-brain drug delivery for improved Alzheimer's disease treatment, J Control Release, 2024, 366: 712-731
Xiaolin Hou; Meng Long; Nianping Feng; Yongtai Zhang*; Natural food-derived materials fabricated nanocapsules-dissolving microneedles system for treating primary dysmenorrhea, Food Hydrocolloids, 2023, 144: 109030
Yongtai Zhang; Zhi Wang; Lina Shen; Yanyan Li; Zehui He; Qing Xia; Nianping Feng ; A novel microemulsion-based isotonic perfusate modulated by Ringer's solution for improved microdialysis recovery of liposoluble substances., J Nanobiotechnology, 2018, 16(1): 91
Yongtai Zhang; Qing Xia; Yanyan Li; Zehui He; Zhe Li; Teng Guo; Zhonghua Wu; Nianping Feng; CD44 Assists the Topical Anti-Psoriatic Efficacy of Curcumin-Loaded Hyaluronan-Modified Ethosomes: A New Strategy for Clustering Drug in Inflammatory Skin, Theranostics, 2019, 9(1): 48-64
Yongtai Zhang, Qing Xia, Tong Wu, Zehui He, Yanyan Li, Zhe Li, Xuefeng Hou, Yuanzhi He, Shuyao Ruan, Zhi Wang, Jia Sun, Nianping Feng. A novel multi-functionalized multicellular nanodelivery system for non-small cell lung cancer photochemotherapy. J Nanobiotechnology. 2021, 19(1): 245.
Yongtai Zhang, Zhi Wang, Lina Shen, Yanyan Li, Zehui He, Qing Xia, Nianping Feng. A novel microemulsion-based isotonic perfusate modulated by Ringer's solution for improved microdialysis recovery of liposoluble substances. J Nanobiotechnology. 2018, 16(1): 91.
Shuwen Ma, Jiaqi Li, Lixia Pei, Nianping Feng*, Yongtai Zhang*. Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects. J Pharm Anal. 2023, 13(2): 111-126